What's the Biggest Unanswered Question Raised By Ridley Scott's Prometheus?

Ridley Scott's Prometheus opens stateside today, which means no more tiptoeing around spoilers for those who've seen it. (Obviously, spoilers will follow. You've been warned.) The number one complaint among folks who have now seen the highly anticipated Alien kinda-prequel? So. Many. Unanswered. Questions. So let's jump right into the spoiler goo and get to deciding (and, hopefully, answering) the biggest question prompted by Scott's gorgeous, murky space opus that is left yet unanswered.
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