VIDEO: Zach Galifianakis Asks Jennifer Aniston What U.S. State She'd Blow Up with a Nuclear Bomb

Is there a more reliably funny Internet video series than Between Two Ferns? Whether hosted by Zach Galifianakis or his mustachioed twin brother Seth, the "talk show" (sponsored by Speed Stick!) is a lock to elicit one or two genuine guffaws from viewers. The latest installment finds Galifianakis discussing sexual acts with a very game Tila Tequila, and Weapons of Mass Destruction with a hilariously peeved Jennifer Aniston. More of that would be a welcome career shift for the Just Go With It star. Click ahead to watch the uncomfortable.

[via Funny or Die]