Todd Phillips + Duplass Brothers = Mule?

This is... interesting: Warner Bros. and Todd Phillips have brought in writer/directors Mark and Jay Duplass to have a crack at adapting Mule, Tony D'Souza's novel about a couple who turn to drug trafficking to make it in the recession. Phillips would direct, making the project the first time the Duplasses, who recently drew mixed reviews with Jeff, Who Lives at Home, did not direct one of their scripts. Unless Phillips goes off and spends the next two years on The Hangover Part III, in which case I guess it might be the brothers' first time directing an adaptation. Wait and see, etc. [Deadline]