Talkback: Who Has Been Bill Murray's Best Co-Star?

Yesterday it was announced that Bill Murray had signed on to star in Roman Coppola's upcoming film, A Glimpse Into the Mind of Charles Swan III alongside -- drum roll please -- Charlie Sheen. In honor of this out-of-left-field pairing, let's recall some of Murray's best onscreen partners in film and consider who has been the best.

It's hard to even ponder the best without considering his most frequent collaborator and co-star in the '80s, Harold Ramis. Before the pair's notorious falling out, the Chicago-raised comedic actors appeared alongside each other in Stripes, Ghostbusters, Ghostbusters 2 and Groundhog Day. Ramis also directed the Murray vehicle Caddyshack and co-wroteMeatballs. Although no one remembers Murray and Ramis for their groundbreaking scenes shared or crackling chemistry, Ramis deserves mention as a formidable co-star who could match Murray in wit and dryness if not prickly charisma.

Then there are the co-stars that played pupil to Murray's offbeat professor like Chris Makepeace, who was taught some crucial camp social lessons by Murray's Meatballs counselor and Jason Schwartzman, whose peculiar private school student was taken under the wing of Murray's lonely tycoon in Rushmore. Both actors lured multiple dimensions and a caring quality from Murray, who more often than not has lapsed into the role of incorrigible grump (Groundhog Day and Scrooged) or staple smart aleck (Ghostbusters) during his career.

Richard Dreyfuss turned that pupil-professor relationship on its ear though, when in 1991's What About Bob?, he played the angry therapist and mentor to Murray's obsessive-compulsive patient with stalker tendencies. Although the movie was only a modest box office success, Murray's role as an upbeat optimist -- even in the face of his many phobias -- was a welcome change.

But perhaps most audience members would credit Scarlett Johansson as Murray's best co-star for helping to coax out his most gentle, honest performance ever in Sofia Coppola's Lost in Translation. As an aging actor who forges an unlikely bond with an unhappily married twentysomething (Johansson), Murray allowed himself to be completely vulnerable, finally trading wisecracks for subtle emotion, thoughtfulness and his first Oscar nomination.

Which co-star do you think has been Murray's best? Maybe you consider Johnny Depp (for Ed Wood), Robert Duvall (for Get Low) or Uma Thurman (in Mad Dog and Glory) to be the finest. Either way, we'd love to hear your opinion below.