The biggest obstacle to adapting A Visit From the Goon Squad would be wrangling what the New York Times described as its "spiky, shape-shifting" structure. Across 13 chapters, over eight characters and perspectives are introduced, their stories taking place across a fifty year span, mostly set in New York City but some set in locations as far away as Africa and Italy. (The layout is so confusing that some critics initially described the novel as a collection of short stories.)
While poignant films have been made using a mosaic storytelling format (like Boogie Nights and Pulp Fiction), rarely, if ever, can filmmakers juggle that many POV changes with flashbacks/flashforwards and drastic setting changes -- at least without the use of a DeLorean, a hot tub time machine or a very capable director and budget.
You know what won't work onscreen whether or not it happens chronologically, though? An entire chapter's worth of PowerPoint charts, which Egan uses at one point to chronicle the flippant thoughts of two teenagers who turn out to be the children of another character in the book.
On top of the structure, the kaleidoscope of perspectives and the PowerPoint problem, Egan's A Visit From the Goon Squad does not have many happy endings. It trades happy-go-lucky characters for embittered industry failures, kleptomaniacs, coke fiends and most tragically, characters grieving lost time and unreached goals. Sadly, even if these, well, sad pieces amount to a critically lauded piece of literature, that doesn't mean that A Visit From the Goons is going to be adapted before a chick lit beach read in which Kate Hudson can star.
VERDICT: If Egan is willing to compromise the Pulitzer Prize-winning structure of her work...and find a way to adapt those 70 plus pages of PowerPoint charts for the screen...and settle for a slightly more uplifting ending, Hollywood might have another adaptation on its hands. Even then, like many novels, A Visit From the Goon Squad will probably still best be enjoyed in old-fashioned book format.